pustluk:

Yesterday morning I got a call from a nurse at my doctor’s office to tell me my most recent round of lab results. I was surprised when the call was cheerily punctuated with, “Remember, too much estrogen converts to testosterone and undoes your changes!”.

Countless transgender women have been told the same thing by their HRT prescribers, usually in the same breath as instructions to lower their dosages. Because statements like this leverage anxiety and gender dysphoria, they are extremely persuasive, especially when coming from a place of perceived authority. They have caused many trans women I know personally severe distress and contributed to a feeling of futility in their biomedical transitions, as well as the potential harm of questionably low-dose hormone regimens.

Unlike most transgender women, however, I’m lucky to have had enough education to know this for what it is: not accurate medical information, but a scare tactic meant to dissuade people from deliberate overdose or self-medication.

There is no known pathway for testosterone biosynthesis from estrogens.

Put simply, this just does not occur. We know of no enzyme that “converts” excess estradiol to testosterone.

The opposite process, biosynthesis of estradiol from testosterone, does occur in people regardless of birth assignment through the enzyme aromatase, also called estrogen synthase. This raises the question of whether an abundance of exogenous estradiol could force the reaction to proceed in reverse. This does not, however, appear to be the case.

Aromatase functions through a three-step mechanism involving successive oxidations of testosterone’s C19 methyl group, followed by eliminative aromatization to estradiol [1][2]. 

A detailed mechanistic study found that, while some steps of the catalysis occur in equilibrium even at typical concentrations, aromatase cannot effectively catalyze the reverse reaction even in an abundance of product; while the estrogenic product binds weakly to aromatase, the rate constant of the reverse reaction was too small to be measured and the conversion from androgenic to estrogenic product may be considered one-directional [2]. I would speculate that this owes partially to aromatization energy (in essence, estradiol is a more stable molecule than testosterone), but that’s just a guess.

So, while it is demonstrably false that estrogen can be “converted” to testosterone, we might still assume that practitioners who tell this to patients are acting in good faith, and merely simplifying a different process. This raises another question:

Can estradiol overdose increase testosterone synthesis? Maybe. Should trans women be concerned? No.

It’s been known since the mid-’70s that high levels of endogenous estadiol (E2) exert positive feedback on the release of gonadotropin-releasing hormone (GnRH) [3]. This is, in fact, a major part of the ovulation cycle. Additionally, through the hypothalamic-pituitary-gonadal axis, these GnRH pulses trigger the release of luteinizing hormone (LH), which in turn regulates testosterone synthesis in the Leydig cells of the testes.

It’s possible, then, to imagine a scenario in which highly elevated levels of exogenous serum estradiol—in the case of, say, an accidentally-doubled intramuscular dose—engage the positive feedback loop of the HPG axis, triggering a surge in testosterone production. As best I can tell, this is speculative and has not yet been clinically observed in transgender women on HRT. Similar phenomena called ‘testosterone flares’, however, have been observed during the administration of GnRH and LH agonists for prostate cancer [4]. These flares last only 1 to 3 weeks [4], however, because sustained engagement of the HPG axis positive feedback loop desensitizes the system [5].

None of this, however, should present a concern for trans women on HRT. This is because testosterone flare will not affect anyone under androgen-receptor blockade by cyproterone acetate or bicalutamide [4], nor will it affect anyone whose testosterone biosynthesis has been externally suppressed by drugs like spironolactone [6] or by surgery like orchiectomy.

Moreover, because LH only regulates Leydig cell testosterone secretion, HPG axis positive feedback will have no effect on adrenal testosterone synthesis—a separate process regulated by corticotropin and CRH.

Practitioners who repeat this myth to trans patients might actually believe it, but their patients shouldn’t have to!

[N.B. I am not an endocrinologist. I am a trans person and former research chemist, primarily trained in chemical biology. This post contains information gathered from the biochemical literature, and does not constitute medical advice.]

References

[1] Yoshimoto FK and Guengerich FP (2014). Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase.

J Am Chem Soc; 136, 15016−15025.

[2] Sohl CD and Guengerich FP (2010). Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. J Biol Chem; 285(23): 17734–17743.

[3] Lasley BL, Wang CF and Yen SSC (1975) The effects of estrogen and progesterone on the functional capacity of the gonadotrophs. J Clin Endocrinol Metab; 41,820–826.

[4] Thompson IM (2001). Flare associated with LHRH-agonist therapy.

Rev Urol; 3(Suppl 3): S10–S14.

[5] Magon N (2011). Gonadotropin releasing hormone agonists: Expanding vistas. Indian J Endocrinol Metab; 15(4): 261–267.

[6] Corvol P (1975). Antiandrogenic effect of spirolactones: mechanism of action.

Endocrinology; 97(1):52-8.

leaveharmony:

mooncustafer:

leaveharmony:

I don’ know what to do because the size chart and measuring tape agree that my waist should make the dress should be a size 16, not a ten (my dresses tend to be either 10s, 12s or occasionally 8s).  And my hips a ten, and my bust a 14?  But if I cut the pattern out one way I can’t un-cut it later if that’s wrong and i’m just sitting here staring at it and trying not to cry.  I’m so tired and nothing is ever just simple enough for my useless fat ass to figure it out

Is the pattern from one of the big-name sewing-pattern companies (MCall’s, etc)? Have you measured the pattern pieces and added them up to see if the waist measurement is actually the same size as it says for a 16 on the back of the envelope? Sorry that I’m not putting this very well — basically, the modern commercial patterns tend to include “design ease” which means they come out a couple of sizes bigger than claimed — that’s supposed to be your wiggle room for making adjustments. So you may end up having to go for the size ten, regardless of what it claims you need. Do you have any old sheets or something you can use to do a test version before you cut into the good fabric?

I’ve got more fabric in here than I can store, it’s just if I cut out the pttern in the wrong size to do a test one….

https://blog.bygertie.com/2018/06/25/b6556-sew-along-1-supplies-fabric-and-sizing/

That’s the one I’m working on or…will be.  Her size chart is different than the one on the instructions and it places me more soothingly between a 10 and 12.  I just…don’t want the waist too tight bc if I don’t feel comfortable I won’t wear it, regardless of how it actually looks, bc dysmorphia is a hell of a thing I guess.  I tend to do very generous seam allowances but that’s when I’m making my own frankenstein patterns for stuff i’m not wearing….dolls and the like

Ok. I’d guess, in that case, that you should follow Gertie’s size chart and maybe  pick the larger size, then take it in where needed. If it ends up being really huge, you can always take it apart and cut it down.